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Phrase(s): Desperate diseases must have desperate remedies.
Prov. If you have a seemingly insurmountable problem, you must do things you ordinarily would not do in order to solve it. • Fred: All my employees have been surly and morose for months. How can I improve their morale? Alan: Why not give everyone a raise? Fred: That’s a pretty extreme suggestion. Alan: Yes, but desperate diseases must have desperate remedies.
McGrawhill's American Idioms And Phrasal Verbs